Research

Our work falls into three connected projects. Each one has its own people, its own questions, and its own set of open positions.

Scaling energy production

How do cells like neurons scale energy production based on dynamic firing needs? How is energy production impaired in neurological and neurodegenerative diseases, and what are the consequences? Our recent work highlights a surprising role for proteins commonly aggregated in dementia in the regulation of energy production.

Privileged energy access

How do cells undergoing great metabolic stress ensure that critical cellular functions stay active?

Balancing matter breakdown and synthesis

How do cells react when matter cycling is disrupted? Our recent work demonstrate how anabolic/biosynthetic defects, specifically in N-glycan synthesis, may be an underappreciated facet of lysosomal storage diseases.